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high content screening of small molecules  (Broad Institute Inc)

 
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    Broad Institute Inc high content screening of small molecules
    High Content Screening Of Small Molecules, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/high content screening of small molecules/product/Broad Institute Inc
    Average 90 stars, based on 1 article reviews
    high content screening of small molecules - by Bioz Stars, 2026-05
    90/100 stars

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    Screening of small-molecule compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h

    Journal: Cancer Immunology, Immunotherapy : CII

    Article Title: ANKRD22 participates in the proinflammatory activities of macrophages in the colon cancer tumor microenvironment

    doi: 10.1007/s00262-024-03930-z

    Figure Lengend Snippet: Screening of small-molecule compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h

    Article Snippet: The small-molecule compound library used was the Topscience Database, which comprises 7,272,880 compounds.

    Techniques: Expressing, Derivative Assay